Things To Be Acquainted With Granulation Tissue And Wound Healing Process


We all have been blessed with a body that performs numerous amazing functions. One of the
examples can be taken as the procedure of wound healing that how different body systems assist
in the healing process. Wound healing can be understood as a complex of active procedures of
restoring missing and devitalized cellular structures and tissue layers. There is also a term that
needs to be identified in this case and that is the granulation tissue. We will try to deliver some
useful information regarding both these points.

What Does Granulation Tissue Mean?

It stands for reddish connective tissue which takes place on the surface of the wound when it
heals. When somebody faces an injury, the skin requires to appear again so that the wound heals.
The appearance of granulation tissues means that the body of a person is healthy and working to
develop a new layer of skin which was ragged due to some happenings.

Functioning And Structure Of Granulation Tissue

The color of granulation tissues is red and they obtain this color from the new blood vessels that
are forming to provide nutrients to the tissue. It also has different cells that assist to build a new
structure, obliterate damaged cells, deliver nutrients through blood vessels and protect against
infection. This tissues’ extracellular matrix is made up of cells known as fibroblasts. It tends to
form type 3 collagen that is known as a form of the protein found in the soft tissues of the body.

It is changed by type 1 collagen, which is a sturdier kind of collagen found in organs, tendons,
and bones. One more kind of cell identified inside granulation tissue refers to immune cells like
leukocytes. Their working depends to help eliminate destroyed cells along with safeguarding the
body against bacteria and viruses. Furthermore, blood vessels must form to deliver nutrients as
well as oxygen to both the recently generated cells and the one which assists to develop new
cells. Vascularization is the name of the procedure of forming a network of blood vessels.

When there comes a presence of excess granulation tissue to grows over the wound, leaving an
excess of uneven, gleaming and red tissue called proud flesh. There can be a condition of the
proud flesh to be healthy which means an overgrowth of normal granulation tissue. On the other
hand, it can be unhealthy if it becomes infected. One of the treatment options can be done
through antimicrobials, antibiotics, foam dressing, tapes, creams, surgical removal, etc.

About Wound Healing Process

There are four various phases of wound healing to understand in this section. They are regarded
as hemostasis, inflammatory, proliferative, and maturation.

1. Hemostasis Phase

It is known to be the procedure of the wound being locked by clotting. It initiates when the blood
starts to leak from the body. Firstly, there is a process when the blood vessels tighten to limit the
flow of blood. After that, platelets stick together for sealing the break in the blood vessel’s wall.
In the end, there comes an occurrence of coagulation and strengthen the platelet plug with
threads of fibrin like a molecular binding agent.

2. Inflammatory Phase

It stands for the second stage in the process of wound healing that initiates right after the injury
and when the injured blood vessels leak transudate that is made up of water, protein, and salt,
causing localized swelling. Inflammation has a charge to manage bleeding and prevent infection.
At the time of the inflammatory phase, pathogens, growth factors, and bacteria are eliminated
from the wound area.

3. Proliferative Phase

It is when the wound gets reconstructed with a fresh tissue of collagen and extracellular matrix.
In this kind of a phase, the wound bonds as fresh tissues are developed. Along with that, a new
system of blood vessels must be constructed so the granulation tissue should be healthy.

4. Maturation Phase

It has been given the second name of the remodeling stage of the wound healing process. It takes
place when the collagen gets remodeled from type III to type I and the wound closes completely.
The cells which have been employed for repairing the wound but aren’t required longer gets
eliminated by apoptosis or programmed cell death.

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